GI-MAP Biomarkers Explained

Guides to the biomarkers on the GI-MAP stool test — calprotectin, zonulin, secretory IgA, elastase-1, and key commensal bacteria.

The GI-MAP (Gastrointestinal Microbial Assay Plus) reports 85+ markers from a single stool sample. These guides explain the individual biomarkers — what each one measures and what high or low values may mean. Each is educational and interpreted with a qualified practitioner.

Calprotectin

A marker of intestinal inflammation that helps separate inflammatory from functional gut problems.

Zonulin

A marker of intestinal permeability (“leaky gut”), available as the GI-MAP + Zonulin add-on.

Secretory IgA (sIgA)

The main antibody defending the gut lining — a window into mucosal immunity.

Pancreatic Elastase-1

A stool marker of pancreatic enzyme output and digestion.

Faecalibacterium prausnitzii

An anti-inflammatory, butyrate-producing keystone commensal.

Akkermansia muciniphila

A mucin-degrading keystone microbe linked to gut-barrier and metabolic health.

Medically reviewed by

Madison Ordway, FDN-P

Functional Diagnostic Nutrition Practitioner specializing in gut health, hormone balance and mineral optimization. Madison uses GI-MAP testing in her work with clients and has been featured in US Insider, Women’s Journal and The Science Times. See press features →

Content reviewed against Diagnostic Solutions Laboratory documentation and peer-reviewed literature. Last reviewed 6 July 2026.

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