Anti-gliadin IgA refers to antibodies directed against gliadin, a component of gluten. GI-MAP reports a stool marker, sometimes labeled anti-gliadin sIgA. It is not interchangeable with the blood antibody tests used to investigate celiac disease.
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What the GI-MAP marker measures
The result concerns a fecal antibody measurement rather than microbial DNA. The manufacturer notes that stool anti-gliadin findings do not necessarily correlate with blood levels. A high result must not be translated into a confirmed celiac diagnosis, wheat allergy or a proven cause of symptoms. [1]
How standard celiac testing differs
Celiac assessment commonly uses blood tests such as tissue transglutaminase IgA (tTG-IgA), with total IgA and other tests selected as appropriate. Duodenal biopsy may be needed in the diagnostic pathway. Deamidated gliadin peptide antibodies are also distinct from simply treating every “gliadin IgA” result as the same test. [2]
Why changing gluten intake first can complicate assessment
Celiac blood tests and biopsy interpretation generally depend on gluten exposure. Starting a gluten-free diet before an evaluation can make confirmation harder. Discuss the plan with your clinician before changing your diet for testing purposes; do not begin a gluten challenge on your own if there are allergy or other safety concerns. [3]
What high and normal stool results cannot settle
A high stool value cannot establish the amount of intestinal damage or identify a safe personal gluten dose. A normal result cannot rule out celiac disease. Neither direction independently diagnoses non-celiac gluten sensitivity, which requires consideration of other explanations.
Bring the exact test name and specimen type to the appointment. This prevents a stool antibody result from being mistaken for a validated celiac blood panel.
Common questions
Does anti-gliadin sIgA mean my total secretory IgA is high?
No. Total secretory IgA and an antibody directed at gliadin are different measurements.
Should I remove gluten because this result is high?
The result alone does not establish a dietary prescription. First discuss symptoms and whether celiac or allergy evaluation is needed.
Sources and review
Sources checked October 7, 2026. Manufacturer material describes the test; clinical guidance and research support the interpretation limits.
- Diagnostic Solutions Laboratory: GI-MAP interpretive guide (manufacturer specifications)
- NIDDK: Celiac disease tests
- NIDDK: Diagnosis of celiac disease
Medical review of this article is pending. For a correction or source question, contact GI MAP Test.